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Extended release tablets of potassium chloride

, : Extended release tablets of potassium chloride. Indian Drugs 24(6): 294-297

Controlled release potassium chloride formulation offers a viable solution to the problem of gastrointestinal distress caused by its conventional formulations. U.S.P. XXI, therefore recommends an extended release tablet of Potassium chloride with specific limit of dissolution. This investigation reports suitable tablet formulations with satisfactory tablet properties and appropriate dissolution pattern. Coating of plain Potassium chloride tablets with Eudragits and wax matrix tablets with ethyl cellulose provided the desired control over release of drug.

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Related references

Thomas, W.H., 1973: Measurement of dissolution rates of potassium chloride from various slow release potassium chloride tablets using a specific ion electrode. Journal of Pharmacy and Pharmacology 25(1): 27-34

Lévy, V.G.; Caroli, J., 1971: Hypokalemia, potassium loss and liver cirrhosis. Value of potassium chloride sustained-release tablets. Therapeutique 47(10): 845-851

Lewis, J.G., 1979: The effect on plasma potassium of a combined preparation of frusemide and slow-release potassium chloride (Diumide-K Continus tablets). An open trial was carried out on ten middle-aged and elderly patients in cardiac failure to assess the effect on plasma potassium levels of one or more tablets containing 40 mg frusemide and a controlled-release formulation containing 600 mg potas...

Weis, J., 1971: A new method for testing ulcerogenic effect and in vivo release of potassium chloride from slow-release tablets. Acta Pharmaceutica Suecica 8(6): 661-666

Barlow, C.G., 1965: Release of potassium chloride from tablets. Journal of Pharmacy and Pharmacology 17(12): 822-824

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Liu Zhi Gao; H.X.e Bing, 2002: Domestic felodipine extended release tablets vs imported felodipine extended release tablets in treating hypertension. AIM: Domestic felodipine extended release tablets (ER) vs imported felodipine ER in treating hypertension. METHODS: Sixty-four patients (M 40, F 24; age 67.8 a+-s1.3 a) received domestic felodipine ER 5-10 mg, po, qd for 8 wk. Another sixty four p...

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