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Extended roles in the brain for second messenger systems

, : Extended roles in the brain for second messenger systems. Neuroscience 2(3): 357-372

In neurons, the elongated cell-processes furnished with discrete subsynaptic sites of distinctive structure and enzyme array offer choice terrain for displaying the attributes of messenger-system components. At such sites, messenger-generating and degrading systems are fixed and the nucleotide messengers and some their products are mobile. In different situations, messenger-generating enzymes, degrading enzyme and modulator-components traverse nerve-cell processes; some messenger-activated phosphoproteins also traverse cytoplasm and nuclear membrane. Thus a multiplicity of components is available for carrying and locally modifying and interpreting the signals mediated by the cyclic nucleotides.

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