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Extended schedule transfer of ethanol discrimination

, : Extended schedule transfer of ethanol discrimination. Pharmacology Biochemistry & Behavior 14(1): 23-26

Stimulus control was established in rats with ethanol (600 mg/kg) and saline by employing a 2-lever response choice task and an FR10 (fixed ratio 10) schedule of food reinforcement. Subjects were then tested with an extended schedule procedure in which lever selection and its perserverance were measured under the training conditions and after the administration of pentobarbital at doses of 2-12 mg/kg. With decreasing doses of pentobarbital, drug-lever selection was observed to decline. The dose at which initial lever selection was evenly distributed between the 2 levers (ED50) was determined to be 4 mg/kg. At this dose the perserverance on the ethanol-appropriate lever was not significantly different than that observed after the training dose of ethanol. The perserverance of saline-lever selection produced by saline was observed to be greater than that produced by the training dose of ethanol on the ethanol-lever. The advantages inherent in employing the extended schedule performance procedure in transfer experiments are discussed.

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Accession: 005432671

PMID: 7465606

DOI: 10.1016/0091-3057(81)90098-8

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