+ Translate

Extensibility changes of calcified soft tissue strips from human aorta

, : Extensibility changes of calcified soft tissue strips from human aorta. Canadian Journal of Physiology & Pharmacology 65(9): 1878-1883

Some degree of calcification was noted in more than half of the 59 aortas of individuals aged from 15 to 88 we have examined at autopsy. The calcification, which is determined by x-raying the opened and flat aorta, is in patches. We have studied the influence of calcification on stress versus strain, breaking strength, and modulus of elasticity of strips of aorta to determine its importance in vascular disease. Strips of aortic wall 5 .times. 30 mm were cut with orientation parallel or perpendicular to the vessel axis. Elongation versus load was measured with an Instron tensile testing machine. The true stress and true strain were calculated for both calcified and uncalcified strips from the thoracic and abdominal regions in both orientations. From the stress-strain curve the following values were selected: strain, stress, and slope at 80 mmHg equivalent pressure (1 mmHg = 133.3 Pa); maximum stress, strain, and slope; and breaking stress, strain, and slope if the sample broke. There were statistically significant differences in 13 of the 36 categories between calcified and uncalcified strips. The breaking strength and strain is lower in the calcified strips. The stress-strain curve for the uncalcified strip was mathematically transformed by reducing the amount of elongation so that the curve coincided with that of the calcified strip for eight matched pairs from the same individuals. The calcification appears to immobilize part of the strip, probably causing the boundary of the calcified tissue to be a region of high stress where tissue breakdown can occur.

Accession: 005432768

PMID: 3690406

DOI: 10.1139/y87-291

Download PDF Full Text: Extensibility changes of calcified soft tissue strips from human aorta

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Murungi, J.I.; Thiam, S.; Tracy, R.E.; Robinson, J.W.; Warner, I.M., 2004: Elemental analysis of soft plaque and calcified plaque deposits from human coronary arteries and aorta. Twenty-five samples of soft plaque and calcified plaque deposits from human hearts or aorta were analyzed using inductively coupled plasma-mass spectrometry (ICP-MS). The determined elements were Ca, P, Na, K, Mg, Zn, Cu, Ba, Pb, Fe, Al, Si, and S...

Gloster, J.; Perkins, E.S.; Pommier, M.L., 1957: Extensibility of strips of sclera and cornea. British Journal of Ophthalmology 41(2): 103-110

Higashi, T.; Ito, K.; Nishikawa, Y.; Manabe, Y.; Ozaki, O.; Mimura, T., 1984: Soft-tissue radiography of calcified thyroid nodules. Rinsho Hoshasen. Clinical Radiography 29(8): 869-873

Yamato, M.; Nishimura, G.; Koguchi, Y.; Saotome, K., 1999: Calcified leiomyoma of deep soft tissue in a child. We report the case of a 7-year-old boy with a calcified leiomyoma in the right gluteal muscle. Radiography and CT showed a well-defined soft tissue mass with mulberry-like calcifications that superficially resembled chondroid matrix calcification....

Spencer, Allen, 1997: Purely biochemical distinguishment between two easily grossly recognizable types of focally diseased tissue, calcified and elliptical thickenings , from arch and thoracic/abdominal aorta of seven human males with seriously diseased aortas, 48-71, who had died from natural causes. FASEB Journal 11(9): A1264

Shea, T.E., 1967: Calcified soft-tissue mass in the medial aspect of the thigh. JAMA 200(12): 1050-1052

Miki, Y.; Abe, S.; Tokizaki, T.; Harasawa, A.; Imamura, T.; Matsushita, T., 2007: Imaging characteristics of calcified leiomyoma of deep soft tissue. Journal of Orthopaedic Science 12(6): 601-605

Lopez-Barea, F.; Rodriguez-Peralto, J., L.; Burgos, E.; Gonzalez-Lopez, J., 1994: Calcified leiomyoma of deep soft tissue: Report of a case in childhood. This report illustrates a calcified leiomyoma of deep soft tissue in the left leg of a 6-year-old boy. The tumour was composed of spindle cells arranged in interlacing bundles, between which were multiple small and large areas of calcification. Tu..., E.H.; Kaneko, K.; Rodriguez, R.P., 1995: Calcified soft tissue leiomyoma of the shoulder mimicking a chondrogenic tumor. A case of leiomyoma with prominent calcification in the deep soft tissue of the shoulder is reported. The tumor showed mulberry-like calcifications on radiographs and computed tomography scans. Magnetic resonance imaging (MRI) showed well-circumsc...

Seyss, R., 1967: Calcified metastasis of soft tissue in a mucus producing adenocarcinoma of the lung. Deutsches Medizinisches Journal 18(5): 123-124