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Extension of survival of rat parathyroid allografts dy depletion of ia donor cells plus preoperative cyclosporine






Transplantation (Baltimore) 44(2): 171-174

Extension of survival of rat parathyroid allografts dy depletion of ia donor cells plus preoperative cyclosporine

Methods that avoid chronic immunosuppression of transplant recipients must be developed to eliminate the various risk factors associated with such treatment (e.g., increased infections and malignancies). Pretransplant treatment of the graft with anti-Ia serum plus complement to eliminate "passenger cells" is one such method. An alternative approach is short-term treatment of the recipients with cyclosporine (CsA). In this study, parathyroid glands from Lewis .times. Brown Norway rats were cultured for one week at 37.degree. C and treated with anti-Ia and complement. Treatment glands were transplanted into parathyroidectomized, hypocalcemic Wistar-Furth recipients that had received 30 mg/kg of CsA once a day for the three days prior to transplant. At 1 year posttransplant, 67% of the recipients had functional parathyroid allografts. Control rats (no CsA; fresh, untreated glands) rejected their grafts within 28 days. Controls given three days of CsA and transplanted with fresh, untreated glands all had functional grafts for > 56 days (median survival: 80.5 days). Prolongation of allograft survival with short-term, preoperative CsA demonstrates the efficacy of immunsuppression given only at the time of antigen presentation. This course of CsA allowed for indefinite graft survival when the recipient received a graft previously cultured and treated with Ia antiserum. These results are encouraging and shoudl be evaluated further to determine whether similar approaches will bs useful in human transplants.


Accession: 005432843

PMID: 3307039



Related references

Bloom, A.D.; Economou, S.G.; Gebel, H.M., 1987: Extension of survival of rat parathyroid allografts by depletion of Ia donor cells plus preoperative cyclosporine. Methods that avoid chronic immunosuppression of transplant recipients must be developed to eliminate the various risk factors associated with such treatment (e.g., increased infections and malignancies). Pretransplant treatment of the graft with a...

Bloom A.D.; Economou S.G.; Baker J.W.; Gebel H.M., 1987: Prolonged survival of rat parathyroid allografts after preoperative treatment with cyclosporine. Current Surgery 44(3): 205-207

Bloom, A.D.; Economou, S.G.; Baker, J.W.; Gebel, H.M., 1987: Prolonged survival of rat parathyroid allografts after preoperative treatment with cyclosporine A. Current Surgery 44(3): 205-207

Bloom A.D.; Economou S.G.; Gebel H.M., 1985: Long term survival of parathyroid allografts after preoperative treatment of recipients with cyclosporine a. Human Immunology 14(2): 175-176

Zhang, T.P.; Zhu, Y.; Wang, S.; Guan, H.; Tang, W., 1996: Tolerance to rat parathyroid allograft induced by depletion of Ia+ donor cells plus short course cyclosporine. In this study, Ia+ donor cells of rat parathyroid allografts were depleted by anti-Ia monoclonal antibody plus complement. The secreting function of treated glands as well preserved. Then we transplanted the treated glands into subcapsular of the...

Westra A.L.; Petersen A.H.; Prop J.; Nieuwenhuis P.; Wildevuur C.R.H., 1986: Prolonged survival of heart allografts after recombined treatment with donor cells and cyclosporine. Journal of Heart Transplantation 5(5): 385

Ready, A.R.; Jenkinson, E.J., 1987: Deoxyguanosine-induced survival of class II-expressing fetal mouse thymic allografts is associated with the depletion of donor lymphoid and dendritic cells. Transplantation Proceedings 19(5): 4225-4226

Xu, H.; Chen, T.; Wang, H.Q.; Hua, Y.B.; Wu, W.W., 2007: Combination treatment with donor interleukin-12p35 silenced dendritic cells and cyclosporine induces long-term survival of intestinal allografts in rats. Immune tolerance promises to enhance allograft survival while reducing risks inherent to immunosuppressants. in this study, we evaluated the effect of interleukin (IL)-12p35 silenced dendritic cells (DC) combined with cyclosporine (CsA) on induct...

Gebel, H.M.; Bloom, A.; McErlean, J.; Leifheit, A.K.; Economou, S., 1987: Prolonged survival of endocrine allografts with preoperative cyclosporine A. Transplantation Proceedings 19(1 Pt 2): 946-949

Dumble, L.J.; Masendycz, P.; Mottram, P.L.; Francis, D.M.; Clunie, G.J., 1986: Prolongation of related rabbit skin allografts by preoperative treatment with donor-specific or third-party transfusion and cyclosporine. Transplantation Proceedings 18(2): 355-356