+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Extension of survival of rat parathyroid allografts dy depletion of ia donor cells plus preoperative cyclosporine

Transplantation (Baltimore) 44(2): 171-174

Extension of survival of rat parathyroid allografts dy depletion of ia donor cells plus preoperative cyclosporine

Methods that avoid chronic immunosuppression of transplant recipients must be developed to eliminate the various risk factors associated with such treatment (e.g., increased infections and malignancies). Pretransplant treatment of the graft with anti-Ia serum plus complement to eliminate "passenger cells" is one such method. An alternative approach is short-term treatment of the recipients with cyclosporine (CsA). In this study, parathyroid glands from Lewis .times. Brown Norway rats were cultured for one week at C and treated with anti-Ia and complement. Treatment glands were transplanted into parathyroidectomized, hypocalcemic Wistar-Furth recipients that had received 30 mg/kg of CsA once a day for the three days prior to transplant. At 1 year posttransplant, 67% of the recipients had functional parathyroid allografts. Control rats (no CsA; fresh, untreated glands) rejected their grafts within 28 days. Controls given three days of CsA and transplanted with fresh, untreated glands all had functional grafts for > 56 days (median survival: 80.5 days). Prolongation of allograft survival with short-term, preoperative CsA demonstrates the efficacy of immunsuppression given only at the time of antigen presentation. This course of CsA allowed for indefinite graft survival when the recipient received a graft previously cultured and treated with Ia antiserum. These results are encouraging and shoudl be evaluated further to determine whether similar approaches will bs useful in human transplants.

(PDF 0-2 workdays service: $29.90)

Accession: 005432843

PMID: 3307039

Related references

Prolonged survival of rat parathyroid allografts after preoperative treatment with cyclosporine A. Current Surgery 44(3): 205-207, 1987

Long term survival of parathyroid allografts after preoperative treatment of recipients with cyclosporine a. Human Immunology 14(2): 175-176, 1985

Tolerance to rat parathyroid allograft induced by depletion of Ia+ donor cells plus short course cyclosporine. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 18(6): 457-460, 1996

Prolonged survival of heart allografts after recombined treatment with donor cells and cyclosporine. Journal of Heart Transplantation 5(5): 385, 1986

Deoxyguanosine-induced survival of class II-expressing fetal mouse thymic allografts is associated with the depletion of donor lymphoid and dendritic cells. Transplantation Proceedings 19(5): 4225-4226, 1987

Combination treatment with donor interleukin-12p35 silenced dendritic cells and cyclosporine induces long-term survival of intestinal allografts in rats. Transplantation Proceedings 39(1): 286-288, 2007

Prolonged survival of endocrine allografts with preoperative cyclosporine A. Transplantation Proceedings 19(1 Pt 2): 946-949, 1987

Prolongation of related rabbit skin allografts by preoperative treatment with donor-specific or third-party transfusion and cyclosporine. Transplantation Proceedings 18(2): 355-356, 1986

Donor-specific blood transfusion reduces cyclosporine effect on the survival of canine renal allografts. Transplantation Proceedings 20(3 Suppl 3): 1102-1104, 1988

Survival of cadaveric donor renal allografts in cyclosporine A-treated recipients: the influence of HLA-DR antigen matching. Transplantation Proceedings 20(3): 369-371, 1988