EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Extensions to multi variate normal models for pedigree analysis 2. modeling the effect of shared environment in the analysis of variation in blood lead levels


American Journal of Epidemiology 117(3): 344-355
Extensions to multi variate normal models for pedigree analysis 2. modeling the effect of shared environment in the analysis of variation in blood lead levels
A multivariate normal model for pedigree analysis is applied to blood lead measurements from 617 individuals in 80 familes in Melbourne, Australia, studied in 1977-1978. A new method is introduced for estimating time dependence of the family covariance matrix for blood lead levels; this time dependence can be interpreted as arising from the effects of common family environment on blood lead levels. Methods for the testing of assumptions and detection of outlying pedigrees and outlying individuals are applied. No correlation between blood lead levels of spouses was observed, but an effect of shared family environment was suggested by the difference between an estimated sibling correlation of .apprx. 0.5 for young sibling pairs living together and of .apprx. 0.1 for older siblings no longer living together. As there was no significant polygenic additive effect, the non-zero correlation between older siblings is more likely to be due to continuing effects of (environmental) factors shared in youth, rather than to a polygenic dominant effect. Smoking 20 cigarettes per day is associated with an increase of .apprx. 12% in blood lead level.


Accession: 005432906

PMID: 6829562



Related references

Extensions to multivariate normal models for pedigree analysis. II. Modeling the effect of shared environment in the analysis of variation in blood lead levels. American Journal of Epidemiology 117(3): 344-355, 1983

Extensions to pedigree analysis 4. covariance components models for multi variate traits. American Journal of Medical Genetics 14(3): 513-524, 1983

Power of likelihood analysis to discriminate among genetic models using multi variate phenotypes from pedigree data. Genetics 88(4 PART 2): S6-S7, 1978

Extensions to multivariate normal models for pedigree analysis. Annals of Human Genetics 46(4): 373-383, 1982

Carriers and noncarriers of hemophilia a 1. multi variate analysis of pedigree data screening blood coagulation tests and factor viii variables. Thrombosis Research 25(5): 401-414, 1982

Evaluation of multi variate dates multi variate analysis of variance applied to pharmacological screening analysis. Biometrische Zeitschrift: 99-104, 1975

Segregation analysis of multi variate traits a new approach to genotype discrimination in pedigree data. American Journal of Human Genetics 30(6): 110A, 1978

The effect of sample sizes on the descriptive use of canonical variate analysis in multi variate morphometrics. The University Of British Columbia Second International Congress Of Systematic And Evolutionary Biology, Vancouver, B C , Canada, July 17-24, I+441p University Of British Columbia: Vancouver, B C , Canada Paper : p126, 1980

Extensions to pedigree analysis. IV. Covariance components models for multivariate traits. American Journal of Medical Genetics 14(3): 513-524, 1983

Linear genetic-and-mathematical models and methods of their analysis. VI. Effect of the genotype-environment interrelationship on the assessment of the Pedigree value of animals in various models of breeding. Selskostopanska nauka2(4): 72-75, 1984