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Extensive adeno carcinoma and large cell undifferentiated carcinoma of the lung treated with 5 fluoro uracil vindesine and mitomycin a southwest oncology group usa study


, : Extensive adeno carcinoma and large cell undifferentiated carcinoma of the lung treated with 5 fluoro uracil vindesine and mitomycin a southwest oncology group usa study. Cancer Treatment Reports 66(3): 553-556

Sixty-three previously untreated patients with metastatic non-small cell lung cancer (40 patients with adenocarcinoma and 23 with large cell undifferentiated carcinoma) were treated with combination chemotherapy consisting of 5-FU [5-fluorouracil] (300 mg/m2) given as an i.v. bolus on Days 1-4 and vindesine (3 mg/m2) and mitomycin (10 mg/m2), both given as an i.v. bolus on Day 1 of each treatment course (FEMi). FEMi was repeated at 3-wk intervals for 3 treatment courses and thereafter at 6-wk intervals until disease progression. Major objective responses were seen in 13 of the 63 patients (21%). Minor responses were seen in an additional 12 patients (19%). The median survival for all patients was 23 wk and for responding patients was 38 wk. The pretreatment performance status had a significant effect on the response rate and survival time. Patients having an initial Karnofsky performance score .gtoreq. 70% had a 54% response rate, with a median survival of 42 wk for responding patients. FEMi was well tolerated; 18 patients (29%) did not have any side effects and only five (8%) experienced vomiting.


Accession: 005432915

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Miller, T.P.; Weick, J.K.; Grozea, P.N.; Carlin, D.A., 1982: Extensive adenocarcinoma and large cell undifferentiated carcinoma of the lung treated with 5-FU, vindesine, and mitomycin (FEMi): a Southwest Oncology Group Study. Sixty-three previously untreated patients with metastatic non-small cell lung cancer (40 patients with adenocarcinoma and 23 with large cell undifferentiated carcinoma) were treated with combination chemotherapy consisting of 5-FU (300 mg/m2) give...

Miller T.P.; Mcmahon L.J.; Livingston R.B.; Moon T.E., 1980: Extensive adeno carcinoma and large cell undifferentiated carcinoma of the lung treated with 5 fluoro uracil vincristine and mitomycin c. Patients [56] with extensive (52 with TNM [tumor, node, metastasis] stage III M1 disease and 4 with TNM stage III Mo disease) adenocarcinoma (46 patients) and large cell undifferentiated carcinoma (10 patients) of the lung were treated with combin...

Miller T.P.; Weick J.K.; Grozea P.; Mueller D., 1981: Treatment of advanced adeno carcinoma and large cell undifferentiated carcinoma of the lung with 5 fluoro uracil vincristine or vindesine and mitomycin c a preliminary analysis. Brade, W , G A Nagel And S Seeber (Ed ) Beitraege Zur Onkologie, Contributions to Oncology, Vol 6 Proceedings Of The International Vinca Alkaloid Symposium: Vindesine; Joint Event Of Arbeitsgemeinschaft Internistische Onkologie Der Deutschen Krebsgesellschaft (Internal Oncology Working Group Of The German Cancer Society) And Eli Lilly Gmbh, Germany, Frankfurt Am Main, West Germany, Nov 1980 Xii+458p S Karger: Basel, Switzerland; New York, N Y , Usa Illus Paper P356-362

Anonymous, 1981: Randomized comparison of 5 fluoro uracil and mitomycin c vs 5 fluoro uracil mitomycin c and streptozotocin in pancreatic adeno carcinoma a southwest oncology group usa study

Myers J.W.; Livingston R.B.; Coltman C.A.Jr, 1980: Combination chemo therapy of advanced adeno carcinoma and large cell undifferentiated carcinoma of the lung with 5 fluoro uracil vincristine and mitomycin c. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 21: 453

Miller T.P.; Vance R.B.; Ahmann F.R.; Rodney S.R., 1986: Extensive non small cell lung cancer treated with mitomycin cisplatin and vindesine a southwest usa oncology group study. Ninety-seven previously untreated patients with metastatic non-small cell lung cancer were treated with combination chemotherapy consisting of mitomycin (10 mg/m2) on Day 1, cisplatin (50 mg/m2) on Days 1 and 22, and vindesine (3 mg/m2) on Days 1...

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Miller, T.P.; McMahon, L.J.; Livingston, R.B., 1980: Extensive adenocarcinoma and large cell undifferentiated carcinoma of the lung treated with 5-FU, vincristine, and mitomycin C (FOMi). Fifty-six patients with extensive (52 with TNM stage III M1 disease and four with TNM stage III M0 disease) adenocarcinoma (46 patients) and large cell undifferentiated carcinoma (ten patients) of the lung were treated with combination chemotherap...

Mccracken J.D.; Ray P.; Heilbrun L.K.; Vaitkevicius V.K.; Saiki J.H.; Rivkin S.E.; Rossof A.H.; Moore T.N., 1980: 5 fluoro uracil 1 2 chloroethyl 3 4 methylcyclohexyl 1 nitroso urea and radio therapy with or without testo lactone for localized adeno carcinoma of the exocrine pancreas a southwest oncology group study. Since August 1975, 69 patients with localized pancreatic carcinoma (extent of tumor confined to a 15 cm .times. 15 cm radiotherapy port) received regimen A, comprising radiotherapy (6000 rad) to the tumor area with simultaneous combination chemoth...

Mira, J.G.; Taylor, S.L.; Stephens, R.L.; Chen, T., 1988: Simultaneous chemotherapy-radiotherapy with prophylactic cranial irradiation for inoperable adeno and large cell lung carcinoma: a Southwest Oncology Group Study. From September 1980 to March 1983, 30 cases were registered in a Southwest Oncology Group Study. Twenty-four cases were evaluable and constitute the basis for this report. Patients were diagnosed with adenocarcinoma or large cell lung carcinoma. T...