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Extravascular natural cyto toxicity in man anti k 562 activity of lymph node and tumor infiltrating lymphocytes



Extravascular natural cyto toxicity in man anti k 562 activity of lymph node and tumor infiltrating lymphocytes



International Journal of Cancer 27(3): 265-272



A major distinction is reported between the cytolytic activity of peripheral blood lymphocytes (PBL) and that of lymph-node and tumor-infiltrating lymphocytes (TIL) against targets of the NK[natural killer cell]-sensitive K562 [human erythroleukemia] cell line in short-term 51Cr release assays. In the PBL of normal donors and lung cancer patients in whom disease was advanced, anti-K562 reactivity, though variable, was consistently detectable and this activity could be augmented to a similar extent in patients and controls by treatment of effectors with exogenous interferon (IF). Anti-K562 activity in lymph-node cells (LNC) and TIL was virtually absent and significant levels could not be induced by exposure to IF. This activity was not attributable to coexistent suppressor cells for NK function since admixture of LNC and TIL with normal PBL failed to modulate K562 killing by the latter. K562-reactive NK cells and their precursors may frequently be present at sub-threshold levels in the lymph nodes of tumor-bearing patients and a similar explanation could account for the inactivity of TIL. In the latter situation, actively-induced NK dysfunction in situ incapable of regeneration by IF, and attributable to as yet undefined tumor-associated factors, may also be involved.

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Accession: 005436634

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PMID: 6169658



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