Section 6
Chapter 5,440

Factors affecting the acquisition of resistance to Schistosoma japonicum in the mouse. II. Evidence that resistance to reinfection is not mediated by specific effector mechanisms

Moloney, N.A.; Webbe, G.

Parasitology 89: 361-367


ISSN/ISBN: 0031-1820
PMID: 6334269
Accession: 005439998

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The skin phase of schistosomular migration was neither essential for the induction or expression of acquired resistance since mice given primary infections by the intraperitoneal route were as resistant to intraperitoneal or percutaneous challenge as were mice given their primary infections percutaneously. Serum taken from resistant donors with acute or chronic infections conferred no ability to resist infection on recipient mice. In 2 experiments mice that were deprived of their T-cells were as resistant to infection as intact mice and both types of host had comparable tissue egg loads and liver pathology. In a 3rd experiment the immune-deprived mice had lower tissue egg counts than the intact mice and were less resistant to challenge. Specific immune effector mechanisms may not be involved in acquired resistance to reinfection but rather that resistance is affected by the T-cell independent immunopathology induced by tissue-bound S. japonicum eggs.

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