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Fingerprint inclusions in kidney of mouse globoid cell leukodystrophy twitcher mouse



Fingerprint inclusions in kidney of mouse globoid cell leukodystrophy twitcher mouse



Jikeikai Medical Journal 31(2): 199-202



Morphological characteristics of kidney were investigated in the twitcher mouse, an authentic murine model of human globoid cell leukodystrophy (GLD). Typical myelin-like or fingerprint inclusion were found in renal tubular cells of twitcher kidney. In the cytoplasm, needle-like or twisted tubular inclusions which usually appeared in human globoid cell from nervous tissues were observed. These tubular or twisted inclusions showed similar EM appearance as found in globoid cells from CNS tissues. Mouse Krabbe's disease is not only involved in CNS, but also in visceral organs.

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Accession: 005464368

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