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Fluoride levels in sera and hard tissues of rats consuming fluoride via drinking water



Fluoride levels in sera and hard tissues of rats consuming fluoride via drinking water



Fluoride 17(3): 183-192



The effect of different fluoride [F-] intakes (5, 10, 25, 50 ppm) via drinking water for 4 wk on body weight gain, food and water comsumption, F- level in serum, lower incisor enamel and femur of young rats was examined. In F5, F10, F25 groups compared to control, no significant differences were observed in body weight gain, food and water consumption. In the F50 group body weight gain and food consumption were diminished. After the 4th wk of treatment, elevated serum F- levels in the F- groups were associated with a higher F- content of lower incisor enamel and femur. This animal model may have been suitable for the study of in vitro effects of F- treatment and for the investigation of the effect of F- supply on the salivary gland which had high metabolic activity.

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