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Folate and mineral metabolism in poorly nourished epileptic children

Folate and mineral metabolism in poorly nourished epileptic children

Archives of Neurology 37(12): 772-774

The increasing use of effective anticonvulsant drugs in the management of epilepsy has brought in its train increasing side effects, such as vitamin and mineral deficiencies. Poorly nourished, ambulant, epileptic children (90), who were receiving anticonvulsant medications for at least 1 yr were studied in respect to their folic acid and vitamin D metabolism. Only 11 (12.2%) had borderline or low folate levels. Serum vitamin D levels were low in 5 (8.9%); serum Ca levels were low in 9 (10%); and serum P levels were low in 3 (3.3%). Alkaline phosphatase levels were elevated in 19 (21.1%) but whether these arose from bone or liver was not determined. Height retardation did not correlate with abnormal mineral metabolism.

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Accession: 005474195

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PMID: 7447765

DOI: 10.1001/archneur.1980.00500610052008

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