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Chapter 5,482

Formation of poly butyl 2 cyano acrylate micro capsules and the micro encapsulation of aqueous solutions of iodine 125 labeled proteins

Wood, D.A.; Whateley, T.L.; Florence, A.T.

International Journal of Pharmaceutics 8(1): 35-44

1981


ISSN/ISBN: 0378-5173
Accession: 005481122

Some features of the polymerization reaction of butyl-2-cyanoacrylate at different aqueous/organic solvent interfaces were investigated. The effects of pH and the presence of protein on the formation of microcapsules by in situ interfacial polymerization of butyl-2-cyanoacrylate in water/oil emulsions was studied. [125I]-labeled proteins were used to study the procedure as a method of microencapsulating enzymes or other proteins within potentially biodegradable membranes. Preliminary in vitro degradation studies suggest that degradation of the microcapsules is inhibited by low levels of their breakdown products, thus allowing the storage of the microcapsules as aqueous suspensions for prolonged periods in sealed containers.

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