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Forms of chromium in rat blood treated in vivo and in vitro with chromium 51 sodium chromate and chromium 51 chromium ii chloride



Forms of chromium in rat blood treated in vivo and in vitro with chromium 51 sodium chromate and chromium 51 chromium ii chloride



Eisei Kagaku 32(2): 123-127



The forms of chromium and the interaction of radiolabeled chromium chloride and sodium chromate with the constituents of red blood cells and plasma in vivo and in vitro were investigated by Sephadex gel chromatographic techniques. The major chemical form in plasma treated with trivalent chromium was chromium-binding protein, and that in plasma treated with hexavalent chromium was a low molecular chromium complex possessing high ability to permeate through the red cell membrane. The form of chromium in stroma-free hemolysate after hexavalent chromium treatment was considered to be a chromium complex which bound easily to hemoglobin. After trivalent chromium treatment, a chromium complex binding easily to higher molecular proteins than hemoglobin was found in stroma-free hemolysate.

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Accession: 005481868

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