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Frequency of mycotic infections in children with malignancies treated at a hospital in jena east germany a retrospective study

Frequency of mycotic infections in children with malignancies treated at a hospital in jena east germany a retrospective study

Kinderaerztliche Praxis 49(3): 121-129

The pre-mortem hospital charts and autopsy protocols of 142 children who suffered from malignancies and died during 1968-1979 were analyzed with respect to mycotic infections. Oral thrush and positive fungal cultures from the mouth or rectum were seen in 19 patients (13.4%). Mycotic infections of the digestive tract, unrelated to death, were observed in 5 cases (3.5%). Generalized mycosis as the cause of death during the refractory stage of a malignant disease was seen in 2 children (1.4%). Generalized fungal diseases causing death during the complete remission of a malignoma were observed in 3 children (2.1%). The incidence of heavy mycotic lesions was 7.0%. The relative frequencies of fatal fungal diseases were 3.1% (2/64) in patients with acute lymphoid leukemia, 5.3% (1/19) in acute myoblastic leukemia patients and 13.0% (3/23) in children suffering from non-Hodgkin's lymphoma. Only 5 cases with minor fungal infections were seen among 32 patients with solid tumors. The overall incidence of mycotic complications found in these patients is less than that reported in the literature. This fact may be the result of prophylaxis with the antifungal agent nystatin.

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Accession: 005487680

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