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Functional studies on iron laden alveolar macrophages 2. functional changes observed in alveolar macrophages from guinea pigs after exposure to welding fume



Functional studies on iron laden alveolar macrophages 2. functional changes observed in alveolar macrophages from guinea pigs after exposure to welding fume



Okayama Igakkai Zasshi 95(7-8): 793-802



In order to clarify the relationship of Fe-laden alveolar macrophages to the pathogenesis of arc welder's lung, kinetics and functions of guinea pig alveolar macrophages were assessed by whole-lung lavage 1, 4 and 8 wk after exposure to welding fume. Whole-lung lavage was also performed in unexposed guinea pigs as controls. The number of lavaged cells was low 1 wk after exposure, but exceeded control levels 4 wk after exposure and remained elevated thereafter. The percentage of polymorphonuclear leukocytes was high 1 and 8 wk after exposure and that of macrophages was high 4 wk after exposure. The Fe-loading rate of alveolar macrophages was 0% in controls. It was elevated > 90% 1 wk after exposure and remained elevated thereafter. Chemotaxis to zymosan activated serum and random migration of alveolar macrophages were maximal 1 wk after exposure and significantly greater (P < 0.001) than with controls at all times. The chemotactic differential and chemotactic index were significantly low 4 and 8 wk after exposure (P < 0.05, P < 0.001), compared with those of controls. The phagocytosis of opsonized zymosan particles by alveolar macrophages were significantly lower (P < 0.01), than controls at all times. There was no significant difference in .beta.-galactosidase activity of alveolar macrophages between controls and welding fume-exposed guinea pigs at any time. Superoxide production by alveolar macrophages was maximal 1 wk after exposure and remained significantly high thereafter (P < 0.05), compared with that for controls. Exposure to welding fumes in vivo induced acute and chronic inflammatory reactions and Fe transport probably mediated by alveolar macrophages.

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