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Further effects of nonsteroidal anti inflammatory compounds on blastocyst hatching in vitro and implantation rates in the mouse

Further effects of nonsteroidal anti inflammatory compounds on blastocyst hatching in vitro and implantation rates in the mouse

Biology of Reproduction 25(4): 777-784

When tested in protein-free medium NCTC 109, mouse blastocytes hatching in vitro was inhibited by low doses (< 50 .mu.M) of indomethacin, meclofenamic acid, mefenamic acid and naproxen [prostaglandin inhibitors]. Ketoprofen was not inhibitory within the same concentration range. In medium supplemented with 10% fetal calf serum, meclofenamic acid inhibited hatching above 100 .mu.M but in contrast naproxen had no effect at 500 .mu.M. With ultrafiltration plus high performance liquid chromatography analysis, 92-83% of meclofenamic acid over the range 100-200 .mu.M was bound to 10% fetal calf serum. Cinemicrographic recording of supplemented cultures containing 100-150 .mu.M meclofenamic acid revealed that the principal reason for the inhibition of hatching was the prevention of adequate blastocyst expansion which is a normal prerequisite to hatching in vitro. Intrauterine administration of 160 .mu.M meclofenamic acid to 1 horn of pregnant mice on day 4 significantly reduced the rate of implantation.

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Accession: 005496561

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PMID: 7306651

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