Further experiments on the action of antithymocyte serum in experimental Junín virus infection

Nota, N.R.; Nejamkis, M.R.; Giovanniello, O.A.

Acta Virologica 20(1): 61-65


ISSN/ISBN: 0001-723X
PMID: 7942
Accession: 005497132

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Rabbit anti-mouse thymocyte serum (ATS) administered as late as 7 days after infection suppressed host cell-mediated responsiveness to intracerebrally injected Junin virus, thereby diminishing the morbidity and mortality of this [possible immune-complex] infection. It did not affect the humoral antibody response or the virus titer in brain. Apparently in mouse brain cells Junin virus infection is basically non-cytopathic. Cell-mediated immunity is apparently responsible for morbidity and mortality, and virus is not cleared from brain as in other encephalitides. ATS may be of therapeutic interest by suppressing or diminishing the cell-mediated response to Junin virus.