+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Galactorrhea: a study of 235 cases, including 48 with pituitary tumors

Galactorrhea: a study of 235 cases, including 48 with pituitary tumors

New England Journal of Medicine 296(11): 589-600

An analysis of 235 patients with galactorrhea (5.5 per cent males) showed that 20 per cent of all patients, and 34 per cent of women with associated amenorrhea, had radiologically evident pituitary tumors; these patients had the highest serum prolactin concentrations. The largest single group (32 per cent) consisted of women with idiopathic galactorrhea without amenorrhea; prolactin was normal in 86 per cent of these cases. Five patients had the empty-sella syndrome. Prolactin response was tested in selected patients by thyrotropin-releasing hormone, chlorpromazine, L-dopa, 24-hour sampling and other means. Tests with thyrotropin-releasing hormone were most useful in identifying patients with pituitary tumors. Surgery and radiotherapy lowered prolactin to a similar degree in patients with tumor, but galactorrhea, and amenorrhea often persisted after treatment. The ergot derivatives, bromergocryptine and lergotrile mesylate, lowered prolactin in all 18 patients with idiopathic hyperprolactinemia or pituitary tumor, stopped galactorrhea in over 50 per cent, restored menses in over 70 per cent, and allowed pregnancy in three.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 005500259

Download citation: RISBibTeXText

PMID: 840242

DOI: 10.1056/nejm197703172961103

Related references

Galactorrhea-amenorrhea and hyperprolactinemia associated with pituitary tumors of growth-hormone- and adrenocorticotropic-hormone-secreting cells. A report of two cases. Journal of Reproductive Medicine 29(12): 883-887, 1984

A sequential pituitary stimulation test in normal subjects and in patients with amenorrhea-galactorrhea with pituitary tumors. Journal of Clinical Endocrinology and Metabolism 45(4): 631-640, 1977

Notes on pituitary tumors; including suggestions of others, and personal experiences in 100 cases. Clinical Neurosurgery 3: 1-58, 1955

Pituitary tumors manifesting with amenorrhea-galactorrhea. Harefuah 90(10): 458-462, 1976

Prolactin secretion in pituitary tumors and in galactorrhea syndrome. Endokrynologia Polska 30(3): 225-239, 1979

Galactorrhea in males with tumors in the region of the pituitary gland. Journal of Neurosurgery 35(6): 723-727, 1971

Patho physiology of amenorrhea galactorrhea in patients with and without pituitary tumors. Gynecologic Investigation 7(1/2): 18, 1976

Amenorrhea-galactorrhea-pituitary tumor syndrome (apropos of 3 cases). La Revue Francaise d'Endocrinologie Clinique Nutrition et Metabolisme 2: 229-242, 1961

Evaluation of the pituitary response in 8 cases of amenorrhea-galactorrhea syndromes. Revista Clinica Espanola 142(1): 13-16, 1976

Uterine Adenomatoid Tumors: A Study of Five Cases Including Three Cases of the Rare Leiomyoadenomatoid Variant. Journal of Obstetrics and Gynaecology of India 65(4): 255-258, 2015

Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'. American Journal of Surgical Pathology 24(11): 1447-1464, 2000

Unique features and insights from mucinous tumors of ovary in childhood: clinicopathological study of 15 cases including four premenarchal cases. Fetal and Pediatric Pathology 33(3): 166-175, 2014

Serum prolactin level in basal conditions and after metoclopramide stimulation in women with galactorrhea and in patients with pituitary tumors. Endokrynologia Polska 34(4): 235-243, 1983

Effects of citicholine on pituitary gland function in normal subjects and in cases of idiopathic galactorrhea. La Clinica Terapeutica 94(4): 407-414, 1980

Effect of L-DOPA on serum prolactin in cases of galactorrhea-amenorrhea caused by a pituitary adenoma. Bollettino Della Societa Italiana di Biologia Sperimentale 50(21): 1857-1861, 1974