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Gastric mucosal blood flow the effect of esophageal transection and endoscopic sclerotherapy for treatment of esophageal varices in liver cirrhosis



Gastric mucosal blood flow the effect of esophageal transection and endoscopic sclerotherapy for treatment of esophageal varices in liver cirrhosis



Japanese Journal of Gastroenterology 84(4): 833-839



Esophageal transection or endoscopic sclerotherapy have been benefit for treatment of variceal bleeding from esophagus in patients with the liver cirrhosis, however it is not easy to control gastric hemorrhage due to acute gastric mucosal damage frequently observed in those patients. It has not been clear whether those procedures might affect the gastric mucosal blood flow which provides the gastric microcirculation as pathogenesis of acute gastric mucosal lesion. The effect of esophageal transection and endoscopic sclerotherapy on gastric mucosal blood flow was investigated in 32 patients with esophageal varices, which was endoscopically measured by using hydrogen gas generated by electrolysis. Gastric mucosal blood flows were decreased in the corpus and antrum in patients with liver cirrhosis as compared with those of normal controls. In cases within 3 months after the esophageal transection it temporally decreased in corpus and antrum, however in patients with a long survival showed a trend of recovery of gastric mucosal blood flow. Gastric mucosal blood flow was much decreased in patients indicated for endoscopic sclerotherapy, in whom operation was not indicated because of severely damaged liver function. These investigations showed that the esophageal transection and endoscopic sclerotherapy decreased the gastric mucosal blood flow which involved in part in gastric mucosal damage in patients with esophageal varices due to liver cirrhosis.

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Accession: 005505543

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PMID: 3613223



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