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Genetic and functional analyses of the primary in vitro cyto toxic t lymphocyte response of nzb lymphocytes to h 2 compatible cells

Genetic and functional analyses of the primary in vitro cyto toxic t lymphocyte response of nzb lymphocytes to h 2 compatible cells

Immunogenetics 12(5-6): 445-464

ISSN/ISBN: 0093-7711

Spleen cells from NZB mice make an unexpected primary cytotoxic T lymphocyte (CTL) response to BALB/c cells in vitro. This response is comprised of at least 3 independent components. These include a response to antigens recognized in association with H-2d products, a response to Qa-1b-associated antigens which is not H-2-restricted and a response directed toward antigens not associated with H-2d- or Qa-1b-coded determinants. The last response appears to be the weakest of the 3. Cells from NZB F1 mice which were homozygous (Qa-1a/Qa-1a) or heterozygous (Qa-1a/Qa-1b) for Qa-1 alleles, all responded to BALB/c cells. The NZB CTL response to BALB/c cells probably is not solely dependent on antigens coded for by genes in the H-2D-Tla region for the sensitization or effector phases of the response. The ontogeny of the NZB anti-BALB/c CTL response coincides with that of a number of B cell abnormalities but is shown in experiments with .mu.-suppressed NZB mice to be independent of B cell dysfunction. Studies with (NZB .times. B10.D2)F1 + B10.D2 mice demonstrated that the anti-BALB/c CTL response to antigens coded for outside of Qa-1 is governed by at least 2 genes. Another conventionally H-2-restricted response, that to TNP[trinitrophenyl]-modified isologous cells, is neither significantly cross-reactive nor markedly elevated in NZB mice. Some subsets of NZB T lymphocytes probably are intrinsically abnormal. The possibilities that the apparent hyperreactivity of NZB CTL precursors, evidenced in the response to BALB/c cells, is primary or results from the secondary effects of excess T cell help are discussed.

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Accession: 005512059

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