EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Genetic and functional analyses of the primary in vitro cyto toxic t lymphocyte response of nzb lymphocytes to h 2 compatible cells


Genetic and functional analyses of the primary in vitro cyto toxic t lymphocyte response of nzb lymphocytes to h 2 compatible cells



Immunogenetics 12(5-6): 445-464



ISSN/ISBN: 0093-7711

Spleen cells from NZB mice make an unexpected primary cytotoxic T lymphocyte (CTL) response to BALB/c cells in vitro. This response is comprised of at least 3 independent components. These include a response to antigens recognized in association with H-2d products, a response to Qa-1b-associated antigens which is not H-2-restricted and a response directed toward antigens not associated with H-2d- or Qa-1b-coded determinants. The last response appears to be the weakest of the 3. Cells from NZB F1 mice which were homozygous (Qa-1a/Qa-1a) or heterozygous (Qa-1a/Qa-1b) for Qa-1 alleles, all responded to BALB/c cells. The NZB CTL response to BALB/c cells probably is not solely dependent on antigens coded for by genes in the H-2D-Tla region for the sensitization or effector phases of the response. The ontogeny of the NZB anti-BALB/c CTL response coincides with that of a number of B cell abnormalities but is shown in experiments with .mu.-suppressed NZB mice to be independent of B cell dysfunction. Studies with (NZB .times. B10.D2)F1 + B10.D2 mice demonstrated that the anti-BALB/c CTL response to antigens coded for outside of Qa-1 is governed by at least 2 genes. Another conventionally H-2-restricted response, that to TNP[trinitrophenyl]-modified isologous cells, is neither significantly cross-reactive nor markedly elevated in NZB mice. Some subsets of NZB T lymphocytes probably are intrinsically abnormal. The possibilities that the apparent hyperreactivity of NZB CTL precursors, evidenced in the response to BALB/c cells, is primary or results from the secondary effects of excess T cell help are discussed.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005512059

Download citation: RISBibTeXText

Related references

Genetic and functional analyses of the primary in vitro CTL: response of NZB lymphocytes to H-2-compatible cells. Immunogenetics 12(5-6): 445-463, 1981

Genetic and functional analyses of the primary in vitro Ctl: Response of Nzb lymphocytes to H-2-compatible cells. Immunogenetics 12(1): 445-463, 1981

Chromosome 1 locus required for induction of cyto toxic t lymphocyte response to h 2 compatible cells in nzd mice. Immunogenetics 15(3): 321-326, 1982

Cyto toxic t lymphocyte responsiveness of thymus deficient nu nu mouse lymphocytes fine specificity and cyto toxic t lymphocyte precursor frequency analysis. Immunobiology 160(1): 36, 1981

Cellular interactions in the cytotoxic T lymphocyte response to herpes simplex virus antigens: differential antigen activation requirements for the helper T lymphocyte and cytotoxic T lymphocyte precursors. Journal of Immunology 131(1): 479-484, 1983

Requirement of histocompatible macrophages for the induction of a secondary cytotoxic response to syngeneic tumor cells in vitro. Journal of Immunology 123(1): 43-49, 1979

Induction of cyto toxic t lymphocytes against herpes simplex virus helper cells respond to different forms of virus than do cyto toxic t lymphocyte precursors. Immunobiology 159(1-2): 41, 1981

In vitro growth of cytotoxic human lymphocytes. V. Generation of allospecific cytotoxic lymphocytes to nonimmunogenic antigen by supplementation of in vitro sensitization with partially purified T-cell growth factor. Cellular Immunology 70(2): 248-259, 1982

Frequency analysis of murine cyto toxic t lymphocyte precursors cyto toxic t lymphocyte precursors in the thymus and the spleen evidence that antigen driven post thymic expansion of h 2 restricted cyto toxic t lymphocyte precursors is responsible for the high degree of allo reactivity. Immunobiology 160(1): 84, 1982

Human cyto toxic t lymphocytes induced by phyto hem agglutinin conditions for cyto toxic t lymphocyte generation and effect of interferon. Japanese Journal of Medical Science and Biology 35(5-6): 221-230, 1982

In vitro primary stimulated lymphocytes immuno genetics of the secondary proliferative response and the secondary cyto toxic response. Annales d'Immunologie (Paris) 126C(3): 360, 1975

Lymphocyte mediated cyto toxicity against allogeneic tumor cells 4. fine specificity mapping and characterization of concanavalin a activated cyto toxic effector lymphocytes. Immunology 44(4): 685-694, 1981

Functional deletion of t cells required for in vitro tri nitro phenyl specific cyto toxic t lymphocyte generation following acute or chronic tolerance induction. Immunobiology 163(2-4): 157, 1982

Requirements for cyto toxicity to human acute myeloid leukemia cells by in vitro generated cyto toxic lymphocytes. Proceedings of the American Association for Cancer Research 18: 232, 1977

Specificity of cyto toxic action of rat lymphocytes stimulated in vitro in mixed lymphocyte culture. Annals of Immunology 6(1-2): 67-76, 1974