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Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide

Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide

Cell 35(3 PART 2): 639-646

The pluripotential hematopoietic stem cell is influenced by at least 1 gene that differs between DBA/2 and C3H/He, and C57BL/6 inbred mouse strains. This gene(s) manifests itself by its effect on susceptibility to killing of spleen colony forming cells (CFU-S) caused by hydroxyurea (HU). In strains DBA/2 and C3H/He 20% of the CFU-S population is normally in S phase whereas practically none from strain C57BL/6 are synthesizing DNA. On the other hand, in C57BL/6 .tautm. DBA/2 allophenic mice the proportion of DBA/2 erythrocytes was higher than the proportion of DBA/2 lymphocytes; the fraction of platelets and neutrophils with the DBA/2 genotype fell between the values for erythrocytes and lymphocytes. Control experiments using mice congenic at the Fv-2 locus confirm that in both situations effects of a gene(s) other than Fv-2 were examined. For the effect on the S phase fraction of CFU-S, the gene(s) are referred to as Stk (stem cell kinetics). The observed skewing in composition among the various mature blood cell types in C57BL/6 .tautm. DBA/2 allophenic mice apparently is caused by allelic variants of the Stk gene. Such variation would favor the formation of DBA/2 erythrocytes, platelets and neutrophils over those of the C57BL/6 genotype.

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Accession: 005513135

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PMID: 6652681

DOI: 10.1016/0092-8674(83)90096-X

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