+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Genetic influences on splenic function in celiac disease



Genetic influences on splenic function in celiac disease



Gut 26(10): 1004-1007



Splenic function was assessed using 'pitted' erythrocyte counts in 61 first degree relatives of patients with coeliac disease. 'Pitted' erythrocyte counts were normal in 12 parents, but were raised in 20% of 49 siblings and/or children of coeliac patients. First degree relatives had higher 'pitted' erythrocyte counts than normal controls (p = 0.002). The counts were lower in coeliac relatives than in age matched coeliacs (p = 0.0001), but no difference was present between the relatives and coeliac patients whose small bowel mucosa was morphologically normal. Considerable interfamily variation was found in 'pitted' erythrocyte counts, both in the coeliac patients and first degree relatives, and the pattern tended to 'run true' within families. The genetic factor influencing splenic function in coeliac disease is not HLA-linked but seems to be associated with a second, probably recessive, gene influencing the inheritance of coeliac disease.

(PDF emailed within 1 workday: $29.90)

Accession: 005515018

Download citation: RISBibTeXText

PMID: 3876972


Related references

Splenic function in childhood celiac disease. Gut 23(5): 415-416, 1982

Celiac disease splenic function and malignancy. Gut 23(8): 666-669, 1982

Simple method of assessing splenic function in celiac disease. Gut 20(10): A920, 1979

Evaluation of splenic function in infants and adults with celiac disease. Archivio di Medicina Interna 37(4): 215-218, 1985

Is it worth investigating splenic function in patients with celiac disease?. World Journal of Gastroenterology 19(15): 2313-2318, 2014

Res fc receptor function and splenic blood flow in patients with celiac disease. Nuklearmedizin 26(4): 68, 1987

A genetic study of celiac disease; incidence of celiac disease, gastrointestinal disorders, and diabetes in pedigrees of children with celiac disease. A.M.A. Journal of Diseases of Children 91(2): 131-137, 1956

Splenic function and intestinal enzyme activity in celiac relatives is there a celiac trait?. Gut 23(10): A919-A920, 1982

Impairment of splenic IgM-memory but not switched-memory B cells in a patient with celiac disease and splenic atrophy. Journal of Allergy and Clinical Immunology 120(6): 1461-1463, 2007

On the influences of the splenic components of various animals on the experimental hepatic disturbances I Influences of splenic com- ponents of cattle. Japanese Jour Pharmacol: 32-46, 1952

Contribution of KIR genes, HLA class I ligands, and KIR/HLA class I ligand combinations on the genetic predisposition to celiac disease and coexisting celiac disease and type 1 diabetes mellitus. Revista Espanola de Enfermedades Digestivas 107(9): 547-553, 2015