+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Genetic linkage between the AH locus and a major gene that inhibits susceptibility to audiogenic seizures in mice



Genetic linkage between the AH locus and a major gene that inhibits susceptibility to audiogenic seizures in mice



Genetics 99(1): 117-126



Mice of the DBA/2 (D2) strain are highly susceptible to sound-induced seizures at 21 days of age; whereas, mice of the C57BL/6 (B6) strain are resistant to these seizures. Although the difference in susceptibility to audiogenic seizures (ASs) between these two strains is inherited as a multiple-factor trait, an association was observed between susceptibility to ASs and the Ah locus. The Ah locus controls the inducibility of aryl hydrocarbon hydroxylase (AHH) activity by a number of aromatic hydrocarbons. B6 mice carry the Ahb allele and have inducible AHH activity; whereas, D2 mice carry the Ahd allele and have noninducible activity. Inducibility is inherited as a Mendelian dominant trait in crosses between these strains. Mice carrying the Ahb allele are generally less susceptible to ASs sat 21 days of age than are mice carrying the Ahd allele. The combined results from B6 X D2 recombinant inbred strains, congenic strains (where the Ahb allele was placed into the D2 genome and the Ahd allele placed into the B6 genome), the B6D2F1 X D2 backcross generation, and a random survey of various inbred strains, suggest that the association between these two traits is due to genetic linkage, rather than to pleiotrophy or to chance. A major gene that inhibits susceptibility to ASs appears to be closely linked to the Ah locus. This gene has been designated Ias, for inhibition of ASs. A large portion of the genetic variability of AS susceptibility may be due to the segregation of Ias.

(PDF emailed within 1 workday: $29.90)

Accession: 005515182

Download citation: RISBibTeXText

PMID: 7341353


Related references

Genetic linkage between the ah locus and a major gene that causes resistance to audiogenic seizures in mice. Genetics 97(1 SUPPL): S95, 1981

Genetic mapping of a locus (mass1) causing audiogenic seizures in mice. Genomics 49(2): 188-192, 1998

Genetic characterization and mapping of a monogenic epilepsy locus in mice with audiogenic seizures. Neurology 52(6 SUPPL 2): A284, April 12, 1999

Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proceedings of the National Academy of Sciences of the United States of America 88(12): 5408-5412, 1991

Development of susceptibility to audiogenic seizures in DBA/2J and Rb mice: toward a systematic nomenclature of audiogenic seizure levels. Behavior Genetics 10(6): 537-543, 1980

Confirmation of the influence of a chromosome 7 locus on susceptibility to audiogenic seizures. Mammalian Genome 3(5): 250-253, 1992

Dilute locus and audiogenic seizures in mice. Science 136(3513): 318-319, 1962

Genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice. Atherosclerosis 254(): 124-132, 2016

Data on genetic analysis of atherosclerosis identifies a major susceptibility locus in the major histocompatibility complex of mice. Data in Brief 9(): 1067-1069, 2016

Audiogenic seizures, the dilute locus, and phenylalanine hydroxylase in DBA/1 mice. Science 144(3616): 304-305, 1964

The dilute locus, pyridoxine deficiency, and audiogenic seizures in mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 128(3): 635-638, 1968

Identification of a monogenic locus causing juvenile audiogenic seizures in mice. Society for Neuroscience Abstracts 27(1): 62, 2001

Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. Journal of Neuroscience 22(23): 10088-10093, 2002