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Genetic polymorphism and linkage of complement c 6 and complement c 7 in the common marmoset


Genetic polymorphism and linkage of complement c 6 and complement c 7 in the common marmoset



Biochemical Genetics 22(1-2): 51-64



ISSN/ISBN: 0006-2928

Using polyacrylamide gel isoelectric focusing and standard specific hemolytic detection methods, genetic polymorphisms were found in the 6th and 7th complement components (C6 and C7) in 2 laboratory groups of common marmosets. The C6 locus is highly variable and the products of 6 alleles were observed; three C7 alleles were found. Comprehensive breeding data indicated that both sets of alleles are inherited in an autosomal codominant manner. Many of the C6 variants differed only by a minute charge interval. The C7 variant bands differed by large charge intervals and could only be clearly seen in plasmas that were preincubated with neuraminidase. A linkage analysis of C6 and C7 phenotypes in three, 2-generation families gives reasonable evidence that the 2 loci are linked in marmosets as they are in humans.

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Accession: 005515756

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