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Genetic polymorphism of the human complement c 2 presentation of a modified typing technique and data on complement c 2 phenotype distribution linkage genetics and haplotype associations in a norwegian family material

Genetic polymorphism of the human complement c 2 presentation of a modified typing technique and data on complement c 2 phenotype distribution linkage genetics and haplotype associations in a norwegian family material

Human Genetics 42(3): 301-306

ISSN/ISBN: 0340-6717

Proteins were separated by prolonged isoelectric focusing in polyacrylamide gels, whereupon C-2 [complement C-2] bands were detected by a specific hemolytic assay. This was performed by treating the gel with iodine to increase C2 activity, and then developing C2 bands with an agarose gel overlay containing sensitized sheep cells and diluted human serum as a complement source deficient in functional C2. The gene frequencies observed in a material of 122 unrelated adults were C21:0.97 and C22:0.03. C2 linkage relations and C2 haplotype associations were examined in a family material. C2 is very closely linked to HLA loci.

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Accession: 005515931

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