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Genetically controlled immuno globulin m hypo responsiveness to a klebsiella pneumoniae poly saccharide



Genetically controlled immuno globulin m hypo responsiveness to a klebsiella pneumoniae poly saccharide



Immunogenetics 6(1): 81-90



BALB/c mice demonstrate only a very weak primary immune response to the K. pneumoniae polysaccharide (K47-PS). The low response does not result from either a peculiar dose response curve for BALB/c mice or from differing optimal antigen concentrations for high and low responder mice. This variability of response is explicable assuming 2 alleles at a single locus; high responsiveness is dominant. Variability of response is probably not linked to the H-2 [mouse histocompatibility] complex since the low and high responder mice, BALB/c and B10.D2/Sn new line, respectively, share the same H-2 haplotype (H-2d). Tests of F2s, backcrosses, and appropriate congenics have not shown evidence of linkage to sex, the albinism gene, the genes controlling coat color (agouti, black, brown), or the allotype-constant-region genes. The hyporesponsiveness is apparent only in the primary (Ig[immunoglobulin]M) response; hyperimmunization evokes similar antibody titers in high and low responding strains.

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