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Glycosyl sn 1 2 dimyristylphosphatidylinositol is the membrane anchor for trypanosoma equiperdum and trypanosoma congolense variant surface glycoproteins



Glycosyl sn 1 2 dimyristylphosphatidylinositol is the membrane anchor for trypanosoma equiperdum and trypanosoma congolense variant surface glycoproteins



Molecular & Biochemical Parasitology 24(2): 131-136



We have analysed the structures of the Trypanosoma (Nannomonas) congolense and T. equiperdum variant surface glycoprotein (VSG) membrane anchors. Myristic acid uptake, phospholipase treatment, and nitrous acid deamination showed that, for each species the anchor is glycosyl-sn-1,2-dimyristylphosphatidylinositol, as has been previously described for T. brucei. Osmotic lysis of these trypanosomes resulted in the release of soluble VSG, lacking fatty acid. In both species and in T. evansi, an endogenous phospholipase C, which cleaved diacylglycerol from membrane form VSG, was identified.

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