Glycosylated serum proteins and glycosylated hemoglobin in normal pregnancy
Van Dieijen Visser, M.P.; Salemans, T.; Van Wersch, J.W.J.; Schellekens, L.A.; Brombacher, P.J.
Annals of Clinical Biochemistry 23(6): 661-666
1986
ISSN/ISBN: 0004-5632
Accession: 005531781
Glycosylated haemoglobin (HbA1) and glycosylated serum protein concentrations (fructosamine) were monitored in 162 normal pregnancies. The response to the standard 75 g oral glucose tolerance test (OGTT) was used to exclude gestational diabetes. A significant increase in glucose intolerance, measured from the area under the OGTT-curve (r = 0.29, P < 0.0005) and a highly significant decrease in serum albumin concentration (r = -0.79, P < 0.0005) due to the redistribution of body water, as occurs during pregnancy, resulted in a statistically significant decrease in serum fructosamine concentration (r = -0.23, P < 0.01) when related to gestational age in weeks.