Section 6
Chapter 5,532

Glycosylated serum proteins and glycosylated hemoglobin in normal pregnancy

Van Dieijen Visser, M.P.; Salemans, T.; Van Wersch, J.W.J.; Schellekens, L.A.; Brombacher, P.J.

Annals of Clinical Biochemistry 23(6): 661-666


ISSN/ISBN: 0004-5632
Accession: 005531781

Glycosylated haemoglobin (HbA1) and glycosylated serum protein concentrations (fructosamine) were monitored in 162 normal pregnancies. The response to the standard 75 g oral glucose tolerance test (OGTT) was used to exclude gestational diabetes. A significant increase in glucose intolerance, measured from the area under the OGTT-curve (r = 0.29, P < 0.0005) and a highly significant decrease in serum albumin concentration (r = -0.79, P < 0.0005) due to the redistribution of body water, as occurs during pregnancy, resulted in a statistically significant decrease in serum fructosamine concentration (r = -0.23, P < 0.01) when related to gestational age in weeks.

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