Guanethidine - adrenaline eye drops in glaucoma simplex. Pupil behaviour and response of intraocular pressure

Hoyng, P.F.; Dake, C.L.

Documenta Ophthalmologica. Advances in Ophthalmology 51(1-2): 175-181


ISSN/ISBN: 0012-4486
PMID: 7249916
Accession: 005544072

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In the study reported here, the relation between the dilatation of the pupil and the course of intraocular pressure (IOP) is examined in open angle glaucoma patients and in glaucoma suspects after topical administration of the combination of guanethidine 3% and adrenaline 0.5% in 1 eye drop (GA). By treating 1 eye with GA and leaving the fellow eye untreated on the same day, there was a symmetrical response of IOP, independent of the mydriasis in the treated eyes. The mydriatic response has no influence on the course of IOP. The physiological explanation for the symmetrical course of IOP in both treated and untreated fellow eyes seems to be a mediation by the bloodstream of GA to the eye which was left untreated.