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H 2 antigen variants in a cultured hetero zygous mouse leukemia cell line part 3 effect of selection against a d end gene



H 2 antigen variants in a cultured hetero zygous mouse leukemia cell line part 3 effect of selection against a d end gene



Immunogenetics 5(6): 585-596



In previous studies on the emergence of H-2 antigen loss variants from an H-2b/H-2d heterozygous mouse leukemia cell line, it was shown that stable variants could be obtained after a single-step selection procedure with antibody and complement. Selection against the K-end alleles revealed an asymmetry in the types of variant obtained. This paper deals with the results of selection against the D-end alleles. An asymmetry is noticed. Selection against the H-2Dd gene product results in the isolation of stable variants that have lost H-2Dd, either alone or in combination with the linked H-2Kd antigens. Selection against H-2Db, on the other hand, has not, so far, resulted in the isolation of any stable variants. These experiments have not demonstrated unequivocally the mechanism by which these H-2 antigen loss variants are generated. Certain preliminary considerations suggest the possibility that these variants may not, in fact, be true genetic mutants. The alternative, that these variants arose through some nongenetic but stable mechanism, must be considered seriously.

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