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H 2 antigen variants in a cultured hetero zygous mouse leukemia cell line part 5 further cell mediated lympholysis characterization of an h 2d d negative variant



H 2 antigen variants in a cultured hetero zygous mouse leukemia cell line part 5 further cell mediated lympholysis characterization of an h 2d d negative variant



Immunogenetics 8(3): 277-282



An H-2 antigen variant, referred to as -4 + 31 clone 1, was selected by its resistance to an anti-H-2Dd antiserum (BALB.G anti-BALB/c. H-2g anti-H-2d). When tested by cell-mediated cytolysis, this variant was sensitive to cytolytic T [thymus-derived] lymphocytes raised in the same donor-host combination as that used in raising the antiserum. The cell line is resistant to anti-H-2Dd killer cells raised in a more restricted immunization, i.e., BALB.G anti-BALB/c-H-2db, H-2g anti-H-2db. It is sensitive to cytolytic cells raised in (BALB.B .times. BALB/c-H-2db) F1 (H-2b/H-2db) against the BALB/c strain. The variant apparently does not express H-2Dd itself but probably expresses CML target antigens that are missing in the H-2db mutation. This in vitro-isolated variant might be the complementary mutation to the in vivo-obtained H-2db mutation.

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