+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hair pigment patterns in different integumental environments of the mouse influence of the agouti suppressor a s mutation on expression of agouti locus alleles



Hair pigment patterns in different integumental environments of the mouse influence of the agouti suppressor a s mutation on expression of agouti locus alleles



Journal of Heredity 71(4): 229-234



The effect of the agouti suppressor mutation, As, on the pigmentation of hairs in the pelage and special integumental areas of mice was studied. Crosses were made between inbred AsAw/AsAw mice and between these homozygotes and other inbred strains that were cogenic, with the exception of a single gene substitution at the agouti locus. Agouti locus genes included the Avy,Aw,A,atd,at,ax,am and a alleles, which were placed in trans position to the chromosome carrying the AsAw compound. Pigment patterns of the dorsal, flank and ventral hairs of the 1st and 3rd hair generations, and of hairs growing in special integumental areas.sbd.the pinna, tail and hind foot.sbd.were studied. The amount of yellow pigment synthesized by hair bulb melanocytes is both age-dependent, and conditioned by the integumentary environment. In the homozygous As Aw mouse, yellow banding is also influenced by the sex of the animal. In comparison with As Aw heterozygotes, the number of banded hairs in As Aw homozygotes is reduced, and the size of the band is diminished by the extension of the initial period of eumelanin synthesis and by the premature termination of phaeomelanin synthesis. In the heterozygous condition, the As gene had little influence on the pigmentation of hairs in the pelage but increased the amount of eumelanin in the hairs of the special integumental areas. Within genetically uniform integumental tissues, microenvironmental differences occur, and are reflected as alterations in pigment synthesis by hair bulb melanocytes. That such microenvironmental differences can significantly influence gene expression is emphasized by the observation that in the heterozygous state the expression of the As gene is more pronounced in the special integumental area than in the main integument.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005546735

Download citation: RISBibTeXText


Related references

The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles. Journal of Experimental Zoology 220(1): 57-64, 1982

Dermal epidermal interactions and the action of alleles at the agouti locus in the mouse 2. the viable yellow a v y and mottled agouti a m alleles. Developmental Biology 80(2): 495-500, 1980

Expression of genes at the agouti locus and mitotic activity of the hair bulb of the mouse. Genetics 67(4): 559-568, 1971

Molecular analysis of the mouse agouti gene and the role of dominant agouti-locus mutations in obesity and insulin resistance. Molecular and genetic aspects of obesity 158, 1996

Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. Journal of Heredity 86(2): 121-128, 1995

Dermal-epidermal interactions and the action of alleles at the agouti locus in the mouse. Developmental Biology 42(2): 203-210, 1975

Physical and genetic characterization of a 75 kilobase deletion associated with non agouti lethal a recessive lethal allele at the mouse agouti locus. Genetics 121(4): 811-818, 1989

Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics 140(1): 255-265, 1995

Molecular analysis of hypomorphic, homozygous-viable alleles at the mouse agouti locus. Pigment Cell Research 13(3): 210-211, 2000

Effects of agouti alleles, hair plucking, and aging on thiol concentrations in mouse livers. Pigment Cell Research 10(1-2): 108, 1997

Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus. Genetics 160(2): 659-674, 2002

Agouti alleles influence thiol concentrations in hair follicles and extrafollicular tissues of mice (A-y/a, a-wJ/A-wJ, a/a). Pigment Cell Research 8(6): 302-306, 1995

Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques. Journal of Mammalian Evolution 17(3): 211-214, 2010

Differentiation of hairbulb pigment cell melanosomes in compound agouti and albino locus mouse mutants (Ay, a, c2J; C57BL/6J). Pigment Cell Research 3(1): 16-27, 1990

The effect of the "yellow" mutation at the mouse agouti locus on the hormonal profile of pregnancy and lactation. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 95(11): 1254-1257, 2009