+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Heat induced and exercise induced hyper thermia effects on high energy phosphates

Heat induced and exercise induced hyper thermia effects on high energy phosphates

Aviation Space & Environmental Medicine 50(8): 799-802

To assess the role of high energy phosphate compounds in the etiology of heat injury with respect to the release of intracellular constituents, the susceptibility of selected tissues to heat injury and the shock-like demise of the animals, rats were exercised on a treadmill (9.14 m/min) in a hot environment ( C) to a rectal temperature (Tre) of C. In the heart, kidney, left lateral lobe of the liver and gastrocnemius muscle extricated from animals immediately upon termination of the treadmill run, levels of G-6-P, ATP and creatine phosphate (CP) were unchanged when compared with sedentary controls. In animals resuscitated by infusion of isotonic saline into a jugular catheter, levels of CP were significantly (P < 0.025) elevated in gastrocnemius muscle. In rats unconscious and succumbing to the effects of hyperthermic injury, levels of hepatic G-6-P and ATP were significantly reduced (P < 0.05, P < 0.02, respectively). Apparently the combination of exhaustive exercise and heat injury had the most deleterious effects upon hepatic metabolism. While resuscitation with physiological saline may be accompanied by an increased CP synthesis, hyperthermic exhaustion and the concomitant efflux of cellular constituents cannot be attributed to a depletion or even a decrement of high energy phosphates in vital tissues.

(PDF emailed within 1 workday: $29.90)

Accession: 005551178

Download citation: RISBibTeXText

Related references

Heat and exercise induced hyper thermia effects on high energy phosphates creatine phospho kinase and atpase. Federation Proceedings 38(3 PART 1): 1052, 1979

Heat- and exercise-induced hyperthermia: effects on high-energy phosphates. Aviation, Space, and Environmental Medicine 50(8): 799-802, 1979

Effects of eccentric exercise-induced muscle damage on intramyocellular lipid concentration and high energy phosphates. European Journal of Applied Physiology 110(6): 1135-1141, 2011

Porcine malignant hyper thermia 9. changes in the concentrations of intra muscular high energy phosphates glycogen and glycolytic intermediates. British Journal of Anaesthesia 55(7): 635-640, 1983

Effects of age weight and metabolic rate on exercise duration hyper thermia and heat stroke mortality. Federation Proceedings 43(3): ABSTRACT 717, 1984

Endorphin induced hyper thermia characterization of the exogenously and endogenously induced effects. Naunyn-Schmiedeberg's Archives of Pharmacology 309(2): 137-144, 1979

Comparison of the effects of ricin induced and dia thermy induced hyper thermia on cardio respiratory actions of chloroquine. Lomax, P , E Schoenbaum And J Jacob (Ed ) Temperature Regulation And Drug Action Proceedings Of A Symposium Paris, France, April 16-18, Xxii+405p Illus S Karger: Basel, Switzerland; New York, N Y , U S A Isbn 3-8055-1756-4 383-389, 1974

Exercise induced changes in cardiac high energy phosphates in patients with ischemic disease resolve after revascularization. Circulation 82(4 SUPPL 3): III684, 1990

The role of energy in hyper thermia induced mammalian cell inactivation. Radiation Research 83(2): 395, 1980

Hyper thermia induced changes in adriamycin pharmaco kinetics in sarcoma patients receiving whole body hyper thermia adriamycin and cyclo phosphamide. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 22: 260, 1981

Hyper thermia and hypo thermia induced by nonnoxious stress effects of naloxone diazepam and gamma acetylenic gamma amino butyric acid. Life Sciencesppl. 1: 587-590, 1983

Sleep as a response temperature as a possible agent of fatigue induced somnolence abstract cat hyper thermia exercise. Psychophysiology 5(2): 225, 1968

Microwave energy induced localized hyper thermia and radio therapy of malignant tumors. Radiation Research 74(3): 528, 1978

Experimental hyper-thermia induced by the high frequency current. Radiology 16(5): 705-719, 1931