Section 6
Chapter 5,555

Hematological abnormalities in scleroderma. a study of 180 cases

Frayha, R.A.; Shulman, L.E.; Stevens, M.B.

Acta Haematologica 64(1): 25-30


ISSN/ISBN: 0001-5792
PMID: 6774574
DOI: 10.1159/000207206
Accession: 005554020

Download citation:  

Hematological abnormalities in scleroderma indicate a specific complication of the disease itself, or an associated illness. Among 180 patients with scleroderma, anemia was detected in 25% and was attributed to chronic inflammatory disease (usually an overlap syndrome), bleeding mucosal telangiectases as part of the CREST syndrome, intestinal malabsorption, and microangiopathic hemolysis. Leukocytosis, present in 14%, was correlated with active myopathy and/or advanced visceral involvement while leukopenia was suggestive of a crossover with systemic lupus erythematosus. Thrombocytopenia was often a manifestation of microangiopathy, and thrombocytosis was associated with an arteritis or a tumor syndrome.

PDF emailed within 0-6 h: $19.90