Section 6
Chapter 5,555

Haematological changes induced by feeding a common food colour, metanil yellow, in albino mice

Prasad, O.M.; Rastogi, P.B.

Toxicology Letters 16(1-2): 103-107


ISSN/ISBN: 0378-4274
PMID: 6836606
Accession: 005554179

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Metanil yellow was administered daily in the food 0.0, 0.1, 0.5 and 3.0 g/kg body wt for 180 days to albino mice. No change was observed by the first 2 doses but feeding of the color at 3.0 g/kg body wt led to changes in the hematological values. Total erythrocyte count (TEC) and Hb had decreased; ESR [erythrocyte sedimentation rate], MCV [mean corpuscular volume] and mean corpuscular Hb (MCH) had increased. These facts suggested the occurrence of normochromic macrocytic anemia. Differential leukocyte count (DLC) showed marked increase in the number of lymphocytes and monocytes and decrease in the number of neutrophils and eosinophils. Heinz bodies were observed in 80-90% erythrocytes. Other hematological values like total leukocyte count (TLC), platelet count (PC), PCV [packed cell volume], MCHC, bleeding time (BT) and coagulation time (CT) were normal.

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