Section 6
Chapter 5,556

Hemo globin synthesis in somatic cell hybrids independent segregation of the human alpha globin and beta globin genes

Deisseroth, A.; Velez, R.; Nienhuis, A.W.

Science 191(4233): 1262-1264


ISSN/ISBN: 0091-7729
Accession: 005555979

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Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human .alpha.- and .beta.-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human .alpha.- but not the .beta.-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human .beta.- but not the .alpha.-globin gene.

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