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Haemodilution therapy in ischaemic stroke: plasma concentrations and plasma viscosity during long-term infusion of dextran 40 or hydroxyethyl starch 200/0.5


Haemodilution therapy in ischaemic stroke: plasma concentrations and plasma viscosity during long-term infusion of dextran 40 or hydroxyethyl starch 200/0.5



European Journal of Clinical Pharmacology 31(6): 705-710



ISSN/ISBN: 0031-6970

PMID: 2435558

DOI: 10.1007/bf00541299

In 21 patients with ischaemic strokes we have monitored plasma viscosity, total plasma concentration, numeric average molecular weight (Mn), and weight average molecular weight (Mw) of Dextran 40 (dextran) and hydroxyethylstarch 200/0.5 (HES) during 10 days of treatment (days 1-4, 2 .times. 500 ml; days 5-10, 1 .times. 500 ml). Plasma concentrations of dextran increased during the first 4 days (8.3 mg .cntdot. ml-1 on the first day to 18.0 mg .cntdot. ml-1 on the fifth day), reached an apparent steady state of 17.2 mg .cntdot. ml-1 during the next 6 days, and declined subsequently with a half-time (t1/2) of 4.03 days. After ten days treatment Mn and Mw were shifted towards higher values. Plasma viscosity increased from 1.26 mPas to 1.69 mPas on Day 10 (p < 0.01) and was linearly correlated with the total plasma concentration of dextran (p < 0.001; r = 0.88). Total plasma concentrations of HES averaged 11.7 mg .cntdot. ml-1 on Day 1 and 12.4 mg .cntdot. ml-1 on Day 5. The molecular weight distribution did not change during the infusions but decreased in comparison with the administered solution. Plasma viscosity fell from 1.40 mPas to 1.30 mPas at Day 10 (p < 0.05) and was not related to the concentration of HES. The haemodiluting effect, as indicated by a decrease of the haematocrit, was 22% and 16.8% for dextran and HES respectively. These data suggest several advantages of HES compared with dextran in haemodilution therapy of ischaemic stroke.

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