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Histo compatibility antigens controlled by the i region of the murine h 2 complex part 1 mapping of h 2a and h 2c loci



Histo compatibility antigens controlled by the i region of the murine h 2 complex part 1 mapping of h 2a and h 2c loci



Journal of Experimental Medicine 143(6): 1439-1452



Skin grafts were reciprocally exchanged in pairs of congenic [mouse] lines identical in all genes except those located in the central portion of the H-2 complex. Seven such lines were tested: 6R, B10.AQR, A.TL, A.TH, 7R, 9R and B10.HTT. In all donor-recipient combinations at least some grafts were rejected. In combinations differing at the IA subregion (and other central H-2 regions or subregions), all 1st-set grafts were rejected within 3 wk after transplantation and all 2nd-set grafts were rejected within 10 days. In combinations differing at the IC subregion (and other central regions, but not at the IA subregion), 60-100% of 1st-set grafts were rejected but some grafts survived for > 100 days. Most 2nd-set grafts were rejected within 1 mo. after grafting. This behavior of skin grafts indicated the presence of 2 histocompatibility loci in the I region, a strong one and a weak one. This conclusion was confirmed by genetic mapping which placed the strong locus (H-2A) in the IA subregion and the weak locus (H-2C) in the IC subregion. The same strain combinations used for the skin grafting were also used for determination of the capacity of I-region antigens to function as targets in the in vitro cell-mediated lymphocytotoxicity (CML) assay. Spleen cells from mice presensitized in vivo by skin grafting were restimulated in vitro and tested against 51Cr-labeled concanavalin A or lipopolysaccharide blasts. The testing revealed the presence in the I region of 2 loci coding for CML-target antigens. The 2 loci comapped with the H-2A and H-2C loci and were most likely identical to them. As in the skin grafting test, in the CML test, the H-2A antigens evoked stronger response than the H-2C antigens. Rejection of skin grafts across the H-2A and H-2C loci was accompanied by the production of Ia [immune response associated] antibodies. Direct cytotoxic and absorption tests with Ia antibodies directed against antigens coded for by the IC subregion revealed the presence of IaC antigens on epidermal cells. The products of Ia loci may function as transplantation antigens.

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Accession: 005575571

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