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Histological study on effects of anticancer drugs on stomach cancer electron microscopic observation ii. anticancer drug induced changes in human stomach epithelium and cancer cells



Histological study on effects of anticancer drugs on stomach cancer electron microscopic observation ii. anticancer drug induced changes in human stomach epithelium and cancer cells



Journal of Osaka Medical College 44(1): 246



The ultrastructural changes in gastric cancer cells were studied in 43 gastric cancers removed surgically from patients treated with anticancer drug (5FU or FT207). In noncarcinomatous gastric mucosal cells of patients not treated with anticancer drugs, the following changes were seen: coarse nucleolema, agglutination of chromatin and nucleoli, swelling of mitochondria and disappearance of cristae of mitochondria. When anticancer drugs were administered prior to surgery, the following changes were seen in addition: coarse nodular or granular degradation of nucleolar filaments, a decrease in attached ribosomes and a prominent increase in secondary lysosomes. Because of much variety in the shape of nucleoli or intracytoplasmic organelles in the cancer cells, it was often difficult to determine whether or not the anticancer drugs were active against cancer cells. However, cancer cells from patients treated with anticancer drugs prior to surgery showed changes similar to those described in paragraph 2, and a significant decrease in free ribosomes was seen. These ultrastructural changes suggest that the anticancer drugs disturbed the protein synthesis and destroyed the cytoplasmic organelles in cancer cells.

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