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Histoplasma capsulatum infection of abdominal aortic aneurysms

Histoplasma capsulatum infection of abdominal aortic aneurysms

Annals of Surgery 197(1): 57-62

Fungal endarteritis resulting from progressive disseminated histoplasmosis may cause arterial aneurysms, or lead to infection of preexisting aneurysms. Three patients with H. capsulatum infections of abdominal aortic aneurysms are reported. All had previous disseminated histoplasmosis and atherosclerotic peripheral vascular disease. All were considered cured of systemic infection when their aneurysms were discovered. Atherosclerotic vascular lesions may become infected during the course of systemic fungal disease and may serve as a haven for viable organisms in patients whose dissemination recurs despite seemingly adequate antifungal therapy. In treating these patients, resection of all infected arterial tissue, revascularization through uninfected tissues and long-term antimicrobial therapy are recommended.

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Accession: 005581611

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