Human chorionic gonadotropin 2. synthesis of a hexa deca peptide corresponding to the carboxyl terminal sequence 132 147 of the beta subunit of human chorionic gonadotropin
Kawasaki, K.; Kawasaki, C.; Tsuda, Y.; Maeda, M.; Okada, Y.; Yamaji, K.; Takagi, T.; Tanizawa, O.
Chemical and Pharmaceutical Bulletin 28(9): 2692-2698
1980
ISSN/ISBN: 0009-2363 Accession: 005591130
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A hexadecapeptide, H-Arg-Leu-Pro-Gly-Pro-Pro-Asn-Thr-Pro-Ile-Leu-Pro-Gln-Ser-Leu-Pro-OH, corresponding to the C-terminal sequence 132-147 of hCG-.beta. [human chorionic gonadotropin .beta.-subunit] was synthesized stepwise by fragment condensation, assembling 5 fragments [Z[benzyloxycarbonyl]-Arg(NO2)-Leu-Pro-NHNHBoc [butyloxycarbonyl], Z-Gly-Pro-Pro-NHNHBoc, Z-Asn-Thr-Pro-NHNHBoc, Z-Ile-Leu-Pro-NHNHBoc and Z-Gln-Ser-Leu-Pro-OBu+ [t-butoxy]].
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