Section 6
Chapter 5,592

Human chorionic gonadotropin 5. synthesis of a triaconta peptide corresponding to the carboxyl terminal sequence 116 145 of the beta subunit of human chorionic gonadotropin

Okada, Y.; Iguchi, S.; Yagyu, M.; Kawasaki, K.; Yamaji, K.; Takagi, T.; Tanizawa, O.

Chemical and Pharmaceutical Bulletin 28(9): 2714-2719


ISSN/ISBN: 0009-2363
Accession: 005591133

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The triacontapeptide corresponding to sequence 116-145 of the beta-subunit of human chorionic gonadotropin (hCG) according to the amino acid sequence elucidated by Morgan was synthesized by successive azide condensation of 5 peptide fragments, followed by TFA [trifluoroacetic acid] treatment and catalytic hydrogenation. This peptide was conjugated with bovine serum albumin (BSA). A 1% binding of 125I-hCG was observed with the antiserum produced against the conjugate obtained above at a 1:500 dilution.

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