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Hydrogen exchange kinetics in a double helical poly nucleotide with the adenine uracil base pair a use of the n methyl adenine residue

Hydrogen exchange kinetics in a double helical poly nucleotide with the adenine uracil base pair a use of the n methyl adenine residue

Biochimica et Biophysica Acta 656(1): 120-122

ISSN/ISBN: 0005-2728

The kinetics of hydrogen-tritium exchange reactions were followed, using a Sephadex technique, for a double-helical poly(ribo-N6-methyladenylic acid)-poly(ribouridylic acid) complex. Only 1 (but not 2) hydrogen in every N6-methyladenine .cntdot. uracil basepair exchanges at a measurably slow rate (1.2 .cntdot. 10-3 s-1) at C. Thus, the proton exchange between the adenine-amino and uracil-imide groups in a double-helical polynucleotide is considered to be not as fast as has been suggested previously (.apprx. 10 s-1) for an adenine .cntdot. uracil basepair in a monomer system in a non-polar solvent.

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Accession: 005598986

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