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Identification of basic metabolites of 4 4 p chlorobenzoyl piperidino 4 fluoro butyrophenone and experimental neuroleptic agent



Identification of basic metabolites of 4 4 p chlorobenzoyl piperidino 4 fluoro butyrophenone and experimental neuroleptic agent



Drug Metabolism and Disposition 4(6): 562-567



Two metabolites of 4-[4-p(chlorobenzoyl)piperidino]-4'-fluorbutrophenone (RMI 9901) as well as the unchanged drug, were identified in the urine of rats following oral administration of the drug. Analysis of basic urine extracts by combined gas chromatography-mass spectrometry was employed for metabolite identification. N-dealkylation appears to be a major metabolic pathway and results in formation of 4-(p-chlorobenzoyl)piperidine. Subsequent oxidation of this metabolite results in the formation of 4-(p-chlorobenzoyl)-2-piperidone, and represents rather unusual metabolic pathway for compounds of this chemical class.

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