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Immunity induced with ribosomal fraction obtained from salmonella typhi t y 2 against different strains of salmonella typhi



Immunity induced with ribosomal fraction obtained from salmonella typhi t y 2 against different strains of salmonella typhi



Revista Latinoamericana de Microbiologia 17(3): 149-156



Ribosomal preparation obtained from S. typhi T y 2 protected mice against the challenge of 3 different strains of S. typhi. The survival rate of vaccinated animals was 100% vs. 100% death in control animals. The ribosomal preparation did not induce significant protection against the challenge of S. typhimurium-S. typhi hybrid. The mouse acute toxicity test was satisfactory. Toxicity and death were not observed in animals inoculated with high doses of the ribosomal preparations. The tolerance test in human volunteers was restricted to an inflammatory response at the inoculation focus. The mean lesion diameter was maximum at 24-48 h, and disappeared in 96 h.

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