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Immunity to experimental salmonella infection studies of the protective capacity and immunogenicity of lipo poly saccharide acetone killed cells and ribosome rich extracts of salmonella typhimurium in c 3h hej and cd 1 mice



Immunity to experimental salmonella infection studies of the protective capacity and immunogenicity of lipo poly saccharide acetone killed cells and ribosome rich extracts of salmonella typhimurium in c 3h hej and cd 1 mice



Journal of Immunology 121(3): 1010-1014



Phenol-water-extracted lipopolysaccharide [LPS] of S. typhimurium, strain W118-2, was tested for protective capacity and immunogenicity in C3H/HeJ and CD-1 mice 21 days post-vaccination. In C3H/HeJ mice the LPS was not protective and gave no anti-O titer, as measured by passive hemagglutination, whereas in CD-1 mice it was protective and immunogenic. Acetone-killed cells and a ribosomal vaccine prepared from the same strain of Salmonella were protective and resulted in an anti-O titer in the C3H/HeJ and the CD-1 mice. LPS co-extracted with ribosomes, or present in whole cells, is thus more immunogenic for C3H/HeJ mice than phenol-water purified LPS. Ribosome-rich extracts and acetone-killed cells apparently contain substances, in addition to LPS, that modulate the immune response in C3H/HeJ mice. Ribosomal vaccine prepared from a rough strain of S. typhimurium, strain TA1659, that lacks O antigens and makes LPS of the Rc type, did not protect C3H/HeJ or CD-1 mice against Salmonella infection. Mixtures of LPS with ribosomal vaccine derived from this mutant were also tested for their protective capacity. The antigens involved in immunity to Salmonella infection were discussed.

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Accession: 005622480

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PMID: 690428


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