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Immuno depression in human schistosomiasis 1. interaction between schistosomiasis and tuberculin skin test



Immuno depression in human schistosomiasis 1. interaction between schistosomiasis and tuberculin skin test



Cahiers OO.M.-(Office-de-la-Recherche-Scientifique-et-Technique-Outre-Mer)-Serie-Entomologie-Medicale-et-Parasitologie. 20(1): 77-80



Infection with schistosomiasis mansoni depresses the cellular immune system in man, as indicated by the tuberculin skin test reaction before and after treatment. Stools tests of inhabitants of a semi-endemic village revealed 140 infected and 84 healthy individuals. All the villagers were treated with a curative dose of oxamniquine. Tuberculin skin tests were carried out before treatment and 1.3 and 18 mo. after treatment. Paired data analysis was used to compared the induration diameters. After specific anti-schistosome therapy, a significant increase in induration diameter was found among previously parasitized subjects. This demonstrates a schistosome-associated immunodepression of the cellular immune system, which was reversed following elimination of the parasite. There was no increase in the diameter of induration among non-parasitized subjects.

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