+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Immuno pathology of adoptive immunization in mice chronically infected with lymphocytic choriomeningitis virus



Immuno pathology of adoptive immunization in mice chronically infected with lymphocytic choriomeningitis virus



Clinical Immunology and Immunopathology 7(1): 44-52



Adoptive immunization (AI) of mice chronically infected with lymphocytic choriomeningitis (LCM) virus results in a marked reduction in serum virus titer and elevation in serum anti-LCM antibody titer. The histopathology associated with these serological parameters was examined using light and immunofluorescence microscopy. Liver tissue was cleared of LCM antigen within 21 days of cell transfer, thus providing a simple histologic marker for AI in this mouse model of glomerulonephritis. Cytoplasmic LCM antigen in renal tubules and brain was not cleared after AI. Cytoplasmic deposits of mouse immunoglobulin similar to deposits of LCM antigen were noted in several tissues, suggesting a role for antibody in adoptive immunization.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 005626692

Download citation: RISBibTeXText

PMID: 852153


Related references

The effect of adoptive immunization upon the immune complex glomerulo nephritis in mice chronically infected with lymphocytic choriomeningitis virus. Federation Proceedings 36(3): 1062, 1977

Effect of immuno suppression on mice chronically infected with lymphocytic choriomeningitis virus virus. Federation Proceedings 32(3 Part 1): 841, 1973

Studies of the immuno globulin eluted from the glomeruli of mice chronically infected with lymphocytic choriomeningitis virus. Journal of Immunology 119(2): 707-713, 1977

Immuno globulin elution studies from glomeruli of mice chronically infected with lymphocytic choriomeningitis virus. Kidney International 10(6): 546, 1976

Effect of antilymphocyte serum on adoptive immunization of lymphocytic choriomeningitis virus carrier mice. Acta Pathologica et Microbiologica Scandinavica 77(3): 518-526, 1969

Rejection of skin grafts from mice chronically infected with Lymphocytic choriomeningitis virus by non-infected syngeneic recipients. Nature 223(5206): 624, 1969

An apparent histoincompatibility between mice chronically infected with lymphocytic choriomeningitis virus and their uninfected syngeneic counterparts. Transplantation 11(1): 20-29, 1971

Immuno pathologic alterations of lymphatic tissues of mice infected with lymphocytic choriomeningitis virus 2. pathogenetic mechanism. Laboratory Investigation 44(3): 205-213, 1981

Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers. Journal of Experimental Medicine 135(4): 874-889, 1972

Immuno pathologic alterations of lymphatic tissues of mice infected with lymphocytic choriomeningitis virus 1. histo pathologic findings. Laboratory Investigation 44(3): 193-204, 1981

RNA interference-mediated virus clearance from cells both acutely and chronically infected with the prototypic arenavirus lymphocytic choriomeningitis virus. Journal of Virology 79(17): 11071-11081, 2005

Hemopoietic defects in mice infected with lymphocytic choriomeningitis virus part 1 the enhanced x ray sensitivity of virus infected mice. Acta Pathologica et Microbiologica Scandinavica Section B Microbiology & Immunology 80(6): 845-852, 1972

HAEMOPOIETIC DEFECTS IN MICE INFECTED WITH LYMPHOCYTIC CHORIOMENINGITIS VIRUS : 1. The Enhanced X-Ray Sensitivity of Virus Infected Mice. Apmis 80b(6): 845-852, 1973

Haemopoietic defects in mice infected with lymphocytic choriomeningitis virus. 1. The enhanced x-ray sensitivity of virus infected mice. Acta Pathologica et Microbiologica Scandinavica. Section B: Microbiology and Immunology 80(6): 845-852, 1972

Fatal central nervous system disease in lymphocytic choriomeningitis virus carrier mice given lymphocytic choriomeningitis virus immune donor spleen cells. Federation Proceedings 30(2): 353, 1971