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Immunogenic variants obtained by mutagenesis of mouse masto cytoma p 815 2. t lymphocyte mediated cytolysis



Immunogenic variants obtained by mutagenesis of mouse masto cytoma p 815 2. t lymphocyte mediated cytolysis



Journal of Experimental Medicine 152(5): 1184-1193



Tumor cell variants that were rejected by syngeneic mice (tum-) were obtained from [mouse] mastocytoma P815 cells by mutagenesis. A considerable T lymphocyte-mediated lysis was observed upon incubation of these tum- variants with peritoneal exudate cells collected a few days after an i.p. challenge of immune animals. Spleen cells from these animals were cytolytic after stimulation in vitro with the immunizing variant. New antigens, absent from the original P815 tum+ cells, were detected on 15 of the 21 tum- variants tested. All these antigens appeared to be different. No new antigen was detected on any of 10 mutagenized P815 clones that had retained their ability to form tumors. The evidence obtained in vivo and in vitro for the presence of specific antigens on 5 tum- variants was compared. Three variants were shown in vivo and in vitro to carry an individual antigen. One showed no specificity in vivo or in vitro. For 1 variant, no specificity was observed in vivo, although cytolysis tests demonstrated the existence of a singular antigenic specificity.

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Accession: 005630564

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PMID: 6776227


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